<ArticleSet>
<Article>
<Journal>
<PublisherName>Trauma Research Center</PublisherName>
<JournalTitle>Bulletin of Emergency And Trauma</JournalTitle>
<Issn>2322-2522</Issn>
<Volume>5</Volume>
<Issue>4 OCT</Issue>
<PubDate>
<Year>2017</Year>
<Month>10</Month>
<Day>01</Day>
</PubDate>
</Journal>
<ArticleTitle>Local Administration of Methylprednisolone Laden Hydrogel Enhances Functional Recovery of Transected Sciatic Nerve in Rat</ArticleTitle>
<FirstPage>509</FirstPage>
<LastPage>509</LastPage>
<Language>EN</Language>
<AuthorList>
<Author>
<FirstName>Ali</FirstName>
<LastName>Mehrshad</LastName>
<Affiliation>Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran. alimehrshadvmd@gmail.com</Affiliation>
</Author>
<Author>
<FirstName>Mohammad</FirstName>
<LastName>Shahraki</LastName>
</Author>
<Author>
<FirstName>Shahin</FirstName>
<LastName>Ehteshamfar</LastName>
</Author>
</AuthorList>
<History>
<PubDate>
<Year>2017</Year>
<Month>08</Month>
<Day>13</Day>
</PubDate>
<PubDate>
<Year>2017</Year>
<Month>09</Month>
<Day>11</Day>
</PubDate>
<PubDate>
<Year>2017</Year>
<Month>09</Month>
<Day>07</Day>
</PubDate>
</History>
<Abstract>Objective: To determine the effects of methylprednisolone-laden hydrogel loaded into a chitosan conduit on the functional recovery of peripheral nerve using a rat sciatic nerve regeneration model was assessed.Methods: 10-mm sciatic nerve defect was bridged using a chitosan conduit (CHIT/CGP-Hydrogel) filled with CGP-hydrogel. In authograft group (AUTO) a segment of sciatic nerve was transected and reimplanted reversely. In methylprednisolone treated group (CHIT/MP) the conduit was filled with methylprednisolone-laden CGP-hydrogel. The regenerated fibers were studied within 16 weeks after surgery.Results: The behavioral, functional and electrophysiological studies confirmed faster recovery of the regenerated axons in methylprednisolone treated group compared to CHIT/Hydrogel group (p<0.05). The mean ratios of gastrocnemius muscles weight were measured. There was statistically significant difference between the muscle weight ratios of CHIT/MP and CHIT/Hydrogel groups (p<0.05). Morphometric indices of regenerated fibers showed number and diameter of the myelinated fibers were significantly higher in CHIT/MP than in CHIT/Hydrogel group. Conclusion: Methylprednisolone-laden hydrogel when loaded in a chitosan conduit resulted in improvement of functional recovery and quantitative morphometric indices of sciatic nerve.</Abstract>
<ObjectList>
<Object>
<Param>Peripheral nerve repair</Param>
</Object>
<Object>
<Param>Sciatic</Param>
</Object>
<Object>
<Param>Methylprednisolone</Param>
</Object>
<Object>
<Param>Hydrogel</Param>
</Object>
<Object>
<Param>Local</Param>
</Object>
</ObjectList>
</Article>
</ArticleSet>