<ArticleSet>
<Article>
<Journal>
<PublisherName>Trauma Research Center</PublisherName>
<JournalTitle>Bulletin of Emergency And Trauma</JournalTitle>
<Issn>2322-2522</Issn>
<Volume>6</Volume>
<Issue>1 JAN</Issue>
<PubDate>
<Year>2018</Year>
<Month>01</Month>
<Day>01</Day>
</PubDate>
</Journal>
<ArticleTitle>Effects of Aloe Vera and Chitosan Nanoparticle Thin-Film Membranes on Wound Healing in Full Thickness Infected Wounds with Methicillin Resistant Staphylococcus Aureus</ArticleTitle>
<FirstPage>8</FirstPage>
<LastPage>15</LastPage>
<Language>EN</Language>
<AuthorList>
<Author>
<FirstName>Reza</FirstName>
<LastName>Ranjbar</LastName>
<Affiliation>Molecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. rezaranjbar@yahoo.com</Affiliation>
</Author>
<Author>
<FirstName>Alireza</FirstName>
<LastName>Yousefi</LastName>
</Author>
</AuthorList>
<History>
<PubDate>
<Year>2017</Year>
<Month>08</Month>
<Day>28</Day>
</PubDate>
<PubDate>
<Year>2017</Year>
<Month>11</Month>
<Day>21</Day>
</PubDate>
<PubDate>
<Year>2017</Year>
<Month>11</Month>
<Day>11</Day>
</PubDate>
</History>
<Abstract>Objective: To assess effect of Aleo vera with chitosan nanoparticle biofilm on wound healing in full thickness infected wounds with antibiotic resistant gram positive bacteria.Method: Thirty rats were randomized into five groups of six rats each. Group I: Animals with uninfected wounds treated with 0.9% saline solution. Group II: Animals with infected wounds treated with saline. Group III: Animals with infected wounds were dressed with chitosan nanoparticle thin-film membranes. Group IV: Animals with infected wounds were treated topically with Aloe vera and Group V: Animals with infected wounds were treated topically with Aloe vera and dressed with chitosan nanoparticle thin-film membranes. Wound size was measured on 6, 9, 12, 15, 18 and 21days after surgery.Results: Microbiology, reduction in wound area and hydroxyproline contents indicated that there was significant difference (p<0.05) between group V and other groups. Quantitative histological studies and mean rank of the qualitative studies demonstrated that there was significant difference (p<0.05) between group V and other groups.Conclusion: The Aloe vera with chitosan nanoparticle thin-film membranes had a reproducible wound healing potential and hereby justified its use in practice.</Abstract>
<ObjectList>
<Object>
<Param>Aloe vera</Param>
</Object>
<Object>
<Param>Chitosan nanoparticle</Param>
</Object>
<Object>
<Param>Thin-film membrane</Param>
</Object>
<Object>
<Param>MRSA</Param>
</Object>
<Object>
<Param>Wound</Param>
</Object>
<Object>
<Param>Rat</Param>
</Object>
</ObjectList>
</Article>
</ArticleSet>