<ArticleSet>
<Article>
<Journal>
<PublisherName>Trauma Research Center</PublisherName>
<JournalTitle>Bulletin of Emergency And Trauma</JournalTitle>
<Issn>2322-2522</Issn>
<Volume>6</Volume>
<Issue>2 APR</Issue>
<PubDate>
<Year>2018</Year>
<Month>03</Month>
<Day>26</Day>
</PubDate>
</Journal>
<ArticleTitle>Pre-Treatment with Metformin in Comparison with Post-Treatment Reduces Cerebral Ischemia Reperfusion Induced Injuries in Rats</ArticleTitle>
<FirstPage>115</FirstPage>
<LastPage>121</LastPage>
<Language>EN</Language>
<AuthorList>
<Author>
<FirstName>Mojtaba</FirstName>
<LastName>Karimipour</LastName>
<Affiliation>Neurophysiology Research Center, Department of Anatomy, Urmia University of Medical Sciences, Urmia, Iran. mojtaba_karimipour@yahoo.com</Affiliation>
</Author>
<Author>
<FirstName>Sara</FirstName>
<LastName>Shojaei Zarghani</LastName>
</Author>
<Author>
<FirstName>Majid</FirstName>
<LastName>Mohajer Milani</LastName>
</Author>
<Author>
<FirstName>Hamid</FirstName>
<LastName>Soraya</LastName>
</Author>
</AuthorList>
<History>
<PubDate>
<Year>2017</Year>
<Month>11</Month>
<Day>28</Day>
</PubDate>
<PubDate>
<Year>2018</Year>
<Month>02</Month>
<Day>28</Day>
</PubDate>
<PubDate>
<Year>2018</Year>
<Month>02</Month>
<Day>23</Day>
</PubDate>
</History>
<Abstract>Objective: To explore the effects of pre versus post ischemic treatment with metformin after global cerebral ischemia in rats.Methods: Male Wister rats underwent forebrain ischemia by bilateral common carotid artery occlusion for 17 min. Metformin (200 mg/kg) or vehicle was given orally by gavage for 7-14 days. Rats were divided into: control, metformin pre-treatment, metformin post-treatment and metformin pre and post continuous treatment groups. Cerebral infarct size, histopathology, myeloperoxidase and serum malondialdehyde were measured 7 days after ischemia.Results: Histopathological analysis showed that metformin pre-treatment significantly decreased leukocyte infiltration, myeloperoxidase activity and also malondialdehyde level. Metformin pre-treatment and metformin post-treatment reduced infarct size compared with the control group, but it was not significant in the pre and post continuous treatment group.Conclusion: Our findings suggest that pre-treatment with metformin in comparison with post-treatment in experimental stroke can reduce the extent of brain damage and is more neuroprotective at least in part by inhibiting oxidative stress and inflammation.</Abstract>
<ObjectList>
<Object>
<Param>Global cerebral ischemia</Param>
</Object>
<Object>
<Param>Metformin</Param>
</Object>
<Object>
<Param>Oxidative stress</Param>
</Object>
<Object>
<Param>Inflammation</Param>
</Object>
</ObjectList>
</Article>
</ArticleSet>