<ArticleSet>
<Article>
<Journal>
<PublisherName>Trauma Research Center</PublisherName>
<JournalTitle>Bulletin of Emergency And Trauma</JournalTitle>
<Issn>2322-2522</Issn>
<Volume>6</Volume>
<Issue>2 APR</Issue>
<PubDate>
<Year>2018</Year>
<Month>03</Month>
<Day>26</Day>
</PubDate>
</Journal>
<ArticleTitle>Local Xenotransplantation of Bone Marrow Derived Mast Cells (BMMCs) Improves Functional Recovery of Transected Sciatic Nerve in Cat: A Novel Approach in Cell Therapy</ArticleTitle>
<FirstPage>108</FirstPage>
<LastPage>114</LastPage>
<Language>EN</Language>
<AuthorList>
<Author>
<FirstName>Rahim</FirstName>
<LastName>Mohammadi</LastName>
<Affiliation>Department of Internal Medicine and Clinical Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.. r.mohammadi@urmia.ac.ir</Affiliation>
</Author>
<Author>
<FirstName>Dana</FirstName>
<LastName>Anousheh</LastName>
</Author>
<Author>
<FirstName>Mohammad-Hazhir</FirstName>
<LastName>Alaei</LastName>
</Author>
<Author>
<FirstName>Amin</FirstName>
<LastName>Nikpasand</LastName>
</Author>
<Author>
<FirstName>Hawdam</FirstName>
<LastName>Rostami</LastName>
</Author>
<Author>
<FirstName>Rasoul</FirstName>
<LastName>Shahrooz</LastName>
</Author>
</AuthorList>
<History>
<PubDate>
<Year>2018</Year>
<Month>01</Month>
<Day>06</Day>
</PubDate>
<PubDate>
<Year>2018</Year>
<Month>02</Month>
<Day>16</Day>
</PubDate>
<PubDate>
<Year>2018</Year>
<Month>02</Month>
<Day>08</Day>
</PubDate>
</History>
<Abstract>Objective: To determine the effects of bone marrow derived mast cells (BMMCs) on functional recovery of transected sciatic nerve in animal model of cat.Method: A 20-mm sciatic nerve defect was bridged using a silicone nerve guide filled with BMMCs in BMMC group. In Sham-surgery group (SHAM), the sciatic nerve was only exposed and manipulated. In control group (SILOCONE) the gap was repaired with a silicone nerve guide and both ends were sealed using sterile Vaseline to avoid leakage and the nerve guide was filled with 100 μL of phosphate-buffered saline alone. In cell treated group ([SILOCONE/BMMC) the nerve guide was filled with 100 μL BMMCs (2× 106 cells/100 μL). The regenerated nerve fibers were studied, biomechanically, histologically and immunohiscochemically 6 months later.Results: Biomechanical studies confirmed faster recovery of regenerated axons in BMMCs transplanted animals compared to control group (p<0.05). Morphometric indices of the regenerated fibers showed that the number and diameter of the myelinated fibers were significantly higher in BMMCs transplanted animals than in control group (p<0.05). In immunohistochemistry, location of reactions to S-100 in BMMCs transplanted animals was clearly more positive than that in control group.Conclusion: BMMCs xenotransplantation could be considered as a readily accessible source of cells that could improve recovery of transected sciatic nerve.</Abstract>
<ObjectList>
<Object>
<Param>Sciatic nerve</Param>
</Object>
<Object>
<Param>Mast cells</Param>
</Object>
<Object>
<Param>Biomechanical properties</Param>
</Object>
<Object>
<Param>Cats</Param>
</Object>
</ObjectList>
</Article>
</ArticleSet>