<ArticleSet>
<Article>
<Journal>
<PublisherName>Trauma Research Center</PublisherName>
<JournalTitle>Bulletin of Emergency And Trauma</JournalTitle>
<Issn>2322-2522</Issn>
<Volume>6</Volume>
<Issue>3 JUL</Issue>
<PubDate>
<Year>2018</Year>
<Month>06</Month>
<Day>28</Day>
</PubDate>
</Journal>
<ArticleTitle>Interaperitoneal Administration of Αlpha-Tocopherol Loaded Nanoparticles Improves Ischemia-Reperfusion Injury in Rat Ovaries Torsion and Detorsion Model</ArticleTitle>
<FirstPage>207</FirstPage>
<LastPage>216</LastPage>
<Language>EN</Language>
<AuthorList>
<Author>
<FirstName>Alireza</FirstName>
<LastName>Najafpour</LastName>
<Affiliation>Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran. a.najafpour@yahoo.com</Affiliation>
</Author>
<Author>
<FirstName>Houman</FirstName>
<LastName>Azizizadeh</LastName>
</Author>
</AuthorList>
<History>
<PubDate>
<Year>2018</Year>
<Month>02</Month>
<Day>20</Day>
</PubDate>
<PubDate>
<Year>2018</Year>
<Month>05</Month>
<Day>22</Day>
</PubDate>
<PubDate>
<Year>2018</Year>
<Month>05</Month>
<Day>22</Day>
</PubDate>
</History>
<Abstract>Objective: To investigate effects of intraperitoneally administration of α-tocopherol loaded nanoparticles (TNP) on ischemia-reperfusion injury in ovaries.Methods: Thirty-five healthy female Wistar rats ~250g were randomized into seven experimental groups (n = 5): Group SHAM: The rats underwent only laparotomy. Group Ischemia: A 3- hour ischemia only. Group I/R: A 3-hour ischemia and a 3-hour reperfusion. Group I/T: A 3-hour ischemia only and 100 mg/kg intraperitoneal administration (IP) of α-tocopherol 2.5 hours after induction of ischemia. Group I/R/T: A 3-hour ischemia, a 3-hour reperfusion and 100 mg/kg IP of α-tocopherol 2.5 hours after induction of ischemia. Group I/TNP: A 3-hour ischemia only and 1 mg/kg IP of TNP 2.5 hours after induction of ischemia. Group I/R/TNP: A 3-hour ischemia, a 3-hour reperfusion and 1 mg/kg IP of TNP 2.5 hours after induction of ischemia. Results: Animals treated with αTNP showed significantly ameliorated development of ischemia and reperfusion tissue injury compared to those of other groups (p=0.001). The significant higher values of SOD, tGSH, GPO, GSHRd and GST were observed in I/R/NC animals compared to those of other groups (p=0.001). Damage indicators (NOS, MDA, MPO and DNA damage level) were significantly lower in I/R/NC animal compared to those of other groups (p=0.001). Conclusion: Intraperitoneal administration of TNP could be helpful in minimizing ischemia-reperfusion injury in ovarian tissue exposed to ischemia.</Abstract>
<ObjectList>
<Object>
<Param>Ischemia-reperfusion</Param>
</Object>
<Object>
<Param>α-tocopherol nanoparticles</Param>
</Object>
<Object>
<Param>Intraperitoneal</Param>
</Object>
<Object>
<Param>Ovary</Param>
</Object>
</ObjectList>
</Article>
</ArticleSet>