<ArticleSet>
<Article>
<Journal>
<PublisherName>Trauma Research Center</PublisherName>
<JournalTitle>Bulletin of Emergency And Trauma</JournalTitle>
<Issn>2322-2522</Issn>
<Volume>6</Volume>
<Issue>3 JUL</Issue>
<PubDate>
<Year>2018</Year>
<Month>06</Month>
<Day>28</Day>
</PubDate>
</Journal>
<ArticleTitle>Massive Blood Transfusions and Outcomes in Trauma Patients; An Intention to Treat Analysis</ArticleTitle>
<FirstPage>217</FirstPage>
<LastPage>220</LastPage>
<Language>EN</Language>
<AuthorList>
<Author>
<FirstName>Steven</FirstName>
<LastName>Liu</LastName>
<Affiliation>. liusf@natividad.com</Affiliation>
</Author>
<Author>
<FirstName>Quinn</FirstName>
<LastName>Fujii</LastName>
</Author>
<Author>
<FirstName>Farris</FirstName>
<LastName>Serio</LastName>
</Author>
<Author>
<FirstName>Andrew</FirstName>
<LastName>McCague</LastName>
</Author>
</AuthorList>
<History>
<PubDate>
<Year>2018</Year>
<Month>02</Month>
<Day>08</Day>
</PubDate>
<PubDate>
<Year>2018</Year>
<Month>04</Month>
<Day>25</Day>
</PubDate>
<PubDate>
<Year>2018</Year>
<Month>04</Month>
<Day>24</Day>
</PubDate>
</History>
<Abstract>Objective: To determine if there exists an upper limit for amount of blood transfused in trauma patients before it reaches a point of futility.Methods: A prospective cohort study was conducted on 131 patients who received massive blood transfusion (MBT), defined as 10 U or higher of PRBCs received in the initial 24 hours. Data collected from a Level II trauma center registry were used to analyze reports of adult patients from July 2014 to 2017. Cohorts were divided by amount of blood received - 0 to 9 U, 10-19 U, 20 to 29 U, 30-39 U, 40 U or higher - odds ratio for mortality and p-values for mean Injury Severity Score and overall hospital length of stay were calculated for each group.Results: Odds ratios for massive blood transfusion groups from 10 units to 39 units each contained the null value, while our 40 units and above group did not (OR 12.52, 95% CI 1.3-117.7).Conclusion: Although this study is limited by its sample size, these results suggests that 40 units of PRBCs may be a threshold at which survival rates begin to decrease significantly.</Abstract>
<ObjectList>
<Object>
<Param>Massive transfusion</Param>
</Object>
<Object>
<Param>Blood transfusion</Param>
</Object>
<Object>
<Param>Trauma</Param>
</Object>
<Object>
<Param>Blood loss</Param>
</Object>
</ObjectList>
</Article>
</ArticleSet>