<ArticleSet>
<Article>
<Journal>
<PublisherName>Trauma Research Center</PublisherName>
<JournalTitle>Bulletin of Emergency And Trauma</JournalTitle>
<Issn>2322-2522</Issn>
<Volume>7</Volume>
<Issue>1 JAN</Issue>
<PubDate>
<Year>2018</Year>
<Month>12</Month>
<Day>28</Day>
</PubDate>
</Journal>
<ArticleTitle>Effects of Pyrroloquinoline Quinone (PQQ) on Ischemia-Reperfusion Injury in Rat Ovaries: Histological and Biochemical Assessments</ArticleTitle>
<FirstPage>706</FirstPage>
<LastPage>706</LastPage>
<Language>EN</Language>
<AuthorList>
<Author>
<FirstName>Pegah</FirstName>
<LastName>Parhizkar</LastName>
<Affiliation>Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.. pegah_parhizkar@yahoo.com</Affiliation>
</Author>
<Author>
<FirstName>Rahim</FirstName>
<LastName>Mohammadi</LastName>
</Author>
<Author>
<FirstName>Rasoul</FirstName>
<LastName>Shahrouz</LastName>
</Author>
<Author>
<FirstName>Vahid</FirstName>
<LastName>Mohammadi</LastName>
</Author>
</AuthorList>
<History>
<PubDate>
<Year>2018</Year>
<Month>07</Month>
<Day>27</Day>
</PubDate>
<PubDate>
<Year>2018</Year>
<Month>10</Month>
<Day>20</Day>
</PubDate>
<PubDate>
<Year>2018</Year>
<Month>10</Month>
<Day>17</Day>
</PubDate>
</History>
<Abstract>Objective: To evaluate effects of pyrroloquinoline quinone (PQQ) on ischemia-reperfusion injury using a rat ovary model.Method: Thirty healthy female Wistar rats with 250g were randomized into five experimental groups (n = 6): Group SHAM: The rats underwent only laparotomy. Group Ischemia: A 3- hour ischemia only. Group I/R: A 3-hour ischemia and a 3-hour reperfusion. 30 min before termination of reperfusion 20 µL soybeen oil (Solvent of PQQ) was administered. Group I/PQQ: A 3-hour ischemia only and 20 µL (10 mg/kg) intraperitoneal administration (IP) of PQQ 2.5 hours after induction of ischemia. Group I/R/PQQ: A 3-hour ischemia, a 3-hour reperfusion and 20 µL (10 mg/kg) IP of PQQ 2.5 hours after induction of ischemia. Results: Animals treated with PQQ showed significantly ameliorated development of ischemia and reperfusion tissue injury compared to those of other groups (p=0.001). The significant higher values of SOD, GPO and GST were observed in I/R/PQQ animals compared to those of other groups (p=0.001). Damage indicator (MDA) was significantly lower in I/R/PQQ animal compared to those of other groups (p=0.001). Conclusion: Intraperitoneal administration of PQQ could be helpful in minimizing ischemia-reperfusion injury in ovarian tissue exposed to ischemia.</Abstract>
<ObjectList>
<Object>
<Param>Ischemia-reperfusion</Param>
</Object>
<Object>
<Param>Pyrroloquinoline Quinone (PQQ)</Param>
</Object>
<Object>
<Param>Intraperitoneal</Param>
</Object>
<Object>
<Param>Ovary</Param>
</Object>
</ObjectList>
</Article>
</ArticleSet>