<ArticleSet>
<Article>
<Journal>
<PublisherName>Trauma Research Center</PublisherName>
<JournalTitle>Bulletin of Emergency And Trauma</JournalTitle>
<Issn>2322-2522</Issn>
<Volume>7</Volume>
<Issue>2 APR</Issue>
<PubDate>
<Year>2019</Year>
<Month>04</Month>
<Day>01</Day>
</PubDate>
</Journal>
<ArticleTitle>Comparison of Ketamine-Propofol and Ketamine-Thiopental on Bispectral Index Values during Monitored Anesthesia Care (MAC) in Minor Traumatic Orthopedic Surgery; A Randomized, Double-Blind, Clinical Trial</ArticleTitle>
<FirstPage>801</FirstPage>
<LastPage>801</LastPage>
<Language>EN</Language>
<AuthorList>
<Author>
<FirstName>Afsaneh</FirstName>
<LastName>Nowroozi</LastName>
<Affiliation>. drtaleby1000@gmail.com</Affiliation>
</Author>
<Author>
<FirstName>Hanieh</FirstName>
<LastName>Kianipour</LastName>
</Author>
<Author>
<FirstName>Houshang</FirstName>
<LastName>Taleby</LastName>
</Author>
<Author>
<FirstName>Bijan</FirstName>
<LastName>Yazdi</LastName>
</Author>
</AuthorList>
<History>
<PubDate>
<Year>2018</Year>
<Month>11</Month>
<Day>22</Day>
</PubDate>
<PubDate>
<Year>2019</Year>
<Month>02</Month>
<Day>25</Day>
</PubDate>
<PubDate>
<Year>2019</Year>
<Month>01</Month>
<Day>06</Day>
</PubDate>
</History>
<Abstract>Objective: To compare the effects of ketamine-propofol and ketamine-thiopental on bispectral index values during monitored anesthesia care in minor orthopedic surgeries.Methods: This randomized double-blind clinical trial was performed on 90 patients undergoing minor orthopedic surgeries. Participants were randomly allocated to either groups of propofol or thiopental. Bispectral index (BIS), non-invasive arterial blood pressure, SpO2, and electrocardiogram were monitored every 5 minutes. Patients in propofol group received a bolus dose of 0.5 mg/kg ketamine, plus 0.5 mg/kg propofol. In thiopental group, patients received a bolus dose of 0.5 mg/kg ketamine, plus 50-75 mg thiopental. After the surgery, recovery duration, patients’ pain score (VAS) and any intra-operative recall or awareness were recorded. Statistical analysis was performed using SPSS version 19.0Results: BIS was lower in ketamin-propofol group (p< 0.001). Mean arterial blood pressure, heart rate and O2 saturation showed a significant difference between two groups (p< 0.001), which were lower in ketamin–propofol group. VAS score was higher in ketamin-thiopental group (p< 0.001). Both groups were similar in intra-operative recall/awareness.Conclusion: Ketamine-propofol combination deliver a better control over monitored anesthesia during surgery, providing lower BIS, higher O2 saturation and lower heart rate and arterial blood pressure in patients undergoing minor traumatic orthopedic surgeries.Clinical trial registration: IRCT6N 2016032320258</Abstract>
<ObjectList>
<Object>
<Param>Monitored anesthesia care</Param>
</Object>
<Object>
<Param>Ketamin</Param>
</Object>
<Object>
<Param>Propofol</Param>
</Object>
<Object>
<Param>Thiopantal sodium</Param>
</Object>
</ObjectList>
</Article>
</ArticleSet>